Linkage Disequilibrium Testing When Linkage Phase Is Unknown
نویسندگان
چکیده
منابع مشابه
Linkage disequilibrium testing when linkage phase is unknown.
Linkage disequilibrium, the nonrandom association of alleles from different loci, can provide valuable information on the structure of haplotypes in the human genome and is often the basis for evaluating the association of genomic variation with human traits among unrelated subjects. But, linkage phase of genetic markers measured on unrelated subjects is typically unknown, and so measurement of...
متن کاملLinkage disequilibrium between loci with unknown phase.
Linkage disequilibrium is often measured by two statistics, D and r, which can be interpreted as the covariance and the correlation between loci and across gametes. When data consist of diploid genotypes, however, gametes cannot be identified. A variety of iterative statistical methods are used in such cases, all of which assume random mating. Previous work has shown that D and r can be express...
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We describe the use of multivariate regression for testing allelic association in the presence of linkage, using marker genotype data from sibships. The test is valid, provided that the correct mean structure is modeled but does not require the correlation structure within families to be specified. The test can be implemented using standard statistical software such as the SAS programming langu...
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Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...
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1. Abstract 2. Introduction 3. Models and methods 3.1. Haplotype block characterization 3.2. Measure of haplotype block LD 3.3. Test statistic and power calculation 3.4. Population genetic model of haplotype block 4. Results 4.1. Haplotype block LD measure 4.2. Power of the haplotype block LD mapping 4.3. Mapping 5. Discussion 6. Appendix 6.1. Appendix A 6.2. Appendix B 6.3. Appendix C 7. Refer...
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ژورنال
عنوان ژورنال: Genetics
سال: 2004
ISSN: 1943-2631
DOI: 10.1534/genetics.166.1.505